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2023 1

2021 1

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ferroptosis 2

FAF2 1

antioxidation 1

human disease 1

iron metabolism 1

lipid peroxidation 1

lung cancer 1

orlistat 1

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Zooming in and out of ferroptosis in human disease

Frontiers of Medicine 2023, Volume 17, Issue 2, Pages 173-206 doi: 10.1007/s11684-023-0992-z

Abstract: Ferroptosis is defined as an iron-dependent regulated form of cell death driven by lipid peroxidationUnderstanding the underlying molecular mechanisms of ferroptosis and its regulatory pathways could provideIndeed, there are an expanding number of studies suggesting that ferroptosis serves as a bona-fide targetIn this review, we summarize the progress in the research into ferroptosis and its regulatory mechanismsin human disease, while providing evidence in support of ferroptosis as a target for the treatment of

Keywords： ferroptosis human disease iron metabolism lipid peroxidation antioxidation

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Orlistat induces ferroptosis-like cell death of lung cancer cells

Frontiers of Medicine 2021, Volume 15, Issue 6, Pages 922-932 doi: 10.1007/s11684-020-0804-7

Abstract: orlistat, as a single agent, inhibited the proliferation and viabilities of lung cancer cells and induced ferroptosis-likeMechanistically, we found that orlistat reduced the expression of GPX4, a central ferroptosis regulator

Keywords： orlistat ferroptosis FAF2 lung cancer